![]() The anti-apoptotic effect of Maplifa™ was further supported by the decreased levels of apoptosis associated enzymes including caspases-3/7 and -8 in HaCaT cells by 49.5 and 19.0%, respectively. Maplifa™ and GA also showed cytoprotective effects by reducing H2O2-induced apoptosis in HaCaT cells by 8.0 and 7.2%, respectively. Treatment of Maplifa™ (50 μg mL-1) and GA (50 μM) increased the viability of H2O2- and MGO-treated cells by 22.0 and 15.5%, respectively. H2O2 and MGO (both at 400 μM) induced toxicity in HaCaT cells and reduced their viability to 59.2 and 61.6%, respectively. Herein, we investigated the cytoprotective effects of Maplifa™ and GA against hydrogen peroxide (H2O2) and methylglyoxal (MGO)-induced oxidative stress in human keratinocytes (HaCaT cells). A proprietary red maple (Acer rubrum) leaf extract (Maplifa™) and its major phenolic compound, ginnalin A (GA), have been reported to show antioxidant, anti-melanogenesis, and anti-glycation effects but their protective effects against oxidative stress in human skin cells remain unknown. ![]() Phytochemicals from functional foods are common ingredients in dietary supplements and cosmetic products for anti-skin aging effects due to their antioxidant activities. Cytoprotective effects of a proprietary red maple leaf extract and its major polyphenol, ginnalin A, against hydrogen peroxide and methylglyoxal induced oxidative stress in human keratinocytes Abstract Source: Hang Ma, Jialin Xu, Nicholas A. DaSilva, Ling Wang, Zhengxi Wei, Liangran Guo, Shelby L. Johnson, Wei Lu, Jun Xu, Qiong Gu, and Navindra P. Seeram.“Cosmetic applications of glucitol-core containing gallotannins from a proprietary phenolic-enriched red maple (Acer rubrum) leaves extract: inhibition of melanogenesis via down-regulation of tyrosinase and melanogenic gene expression in B16F10 melanoma cells” Springer-Verlag Berlin Heidelberg (2017). Therefore, the anti-melanogenic effects of red maple GCGs warrant further investigation of this proprietary natural product extract for potential cosmetic applications. These data indicated that GA was able to: (1) reduce the levels of reactive oxygen species, (2) down-regulate the expression of MITF, TYR, TRP-1, and TRP-2 gene levels in a timedependent manner, and (3) significantly reduce protein expression of the TRP-2 gene. ![]() GA reduced melanin content in murine melanoma B16F10 cells by 79.1 and 56.7% (at non-toxic concentrations of 25 and 50 μM, respectively), and its mechanisms of anti-melanogenic effects were evaluated by using methods including fluorescent probe (DCFDA), real-time PCR, and western blot experiments. The GCGs showed anti-tyrosinase activity with IC50 values ranging from 101.4 to 1047.3 μM and their mechanism of tyrosinase inhibition (using GA as a Electronic supplementary material representative GCG) was evaluated by chelating and computational/modeling studies. ![]() Herein, the anti-tyrosinase and anti-melanogenic effects of a proprietary phenolic-enriched red maple leaves extract were investigated using enzyme and cellular assays. While these glucitol-core containing gallotannins (GCGs) have reported antioxidant and antiglycative effects, they have not yet been evaluated for their cosmetic applications. The red maple (Acer rubrum) is a rich source of phenolic compounds which possess galloyl groups attached to different positions of a 1,5-anhydro-d-glucitol core. CLINICAL STUDIES ON THE FOLLOWING INGREDIENTS: Maple Leaf Complex Cosmetic applications of glucitol-core containing gallotannins from a proprietary phenolic-enriched red maple (Acer rubrum) leaves extract: inhibition of melanogenesis via down-regulation of tyrosinase and melanogenic gene expression in B16F10 melanoma cells Abstract
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If you own the copyright for a submitted picture, Even if you only know of a good picture, please Will you use it?Ī5: We can't promise to use it but we do strongly encourage picture Q5: I have a picture that would make a good APOD. ![]() Never rerun more than two pictures in any given week.ĪPOD,it is still, most probably, a new picture. To only rerun APODs more than one year old to keep the pictures In general, our rerun policy currently is Lastly, rerunning APODs saves us time and Software to handle more sophisticated image file formats has alsoīecome more common, so the picture's sizeĪnd/or format might be new. Higher-resolution image files that can be transferred conveniently. Have larger bandwidth connections, which allows us to post The text and links of each APOD will be new. So although the picture might be old, some of Text and links for rerun pictures will make use of this newlyĪvailable information. Information about old pictures is becoming available over the WWW. Unaware of some really spectacular or important astronomy pictures. Many of our readers have been with us less than a year and are Q4: Have some APOD pictures been run more than once?Ī4: Yes. This is found by clicking "archive" on the link line, or even byĬlicking "Discover the Cosmos" near the top of recent APOD pages. Q3: How can I see an APOD that ran long ago?Ī3: All APODs are archived. Today's APOD link line (near the bottom of the daily page). Q2: How can I easily see yesterday's APOD?Ī2: Click the < less than sign < at the left of We abbreviate thisĪs APOD instead of ApotD because APOD sounds better A1: APOD stands for the Astronomy Picture of the Day. ![]() #7,, ©ABCFAMILY Pretty Little Liars, Bryce Johnson, 'The Remains of the 'A'', Season 3, Ep. Home Sweet Hell Photos SLEEPING DOGS LIE, Bryce Johnson, Melinda Page Hamilton, 2006, ©Samuel Goldwyn Films Pretty Little Liars, Bryce Johnson, 'Crazy', Season 3, Ep. ![]() Through Johnson's portrayal, audiences were won over by Josh's genuineness, and supported his decision to put aside football for the drama club and his forays into unpopular territory even when his girlfriend and best friend (Ron Lester) didn't. Johnson made the most of Josh's human weaknesses, giving the character a realistically resigned reaction to his unsupportive family and distracted girlfriend. He portrayed Josh as the oblivious nice guy, a hit on the social circuit who doesn't revel in so much as not notice the class structure of high school. Playing Josh Ford, a popular golden boy with a beautiful cheerleader girlfriend (Leslie Bibb), a coveted spot on the football team and seemingly perfect existence, Johnson brought added dimension to his character. That same year "Popular" began airing on the network with Johnson as one of the stars of the high school-set comedy-drama's ensemble cast. He next was cast in "Saving Graces," a sitcom for The WB that didn't pass the pilot stage. Not long after, in 1999, he succeeded in his quest and made his screen debut in the MTV soap "Undressed," an at once steamy and silly program in the network's late night lineup. With only community college acting classes to his credit, he picked up odd jobs, acted in student films and enrolled at Pasadena's American Academy of Dramatic Arts. A blonde actor with All-American good looks and a charming screen presence, Bryce Johnson headed for Hollywood at age 19, determined to make it in show business. ![]() At BTI we sure you can find all the product that you want. It featured the original main cast as well as a variety of other special characters who often got their own special roles in their own episodes. dan hadis tentan boarding school, Lalaloopsy games doll factory nick jr. series is a half-hour animated television series that aired on Nickelodeon featuring the colorful rag doll characters from the popular childrens doll line. ![]()
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